A Conjugated Nucleic Acid of Pancreas
نویسنده
چکیده
A recent preliminary communication by Feulgenl on a conjugated nucleic acid of pancreas prompts me to publish my own results on the same subject. Feulgen prepared a nucleic acid from pancreas by enzymatic digestion of p-nucleoprotein. This acid could be split into phosphoric acid, levulinic acid, furfurol, thymine, cytosine, guanine, and adenine. He found that an alkali salt of guanylic acid could be precipitated with sodium acetate after digestion in alkaline solution. The nucleic acid was dextrorotatory. From these data Feulgen assumes his nucleic acid to be of a molecular composition between guanylic acid and tetranucleotide, and calls it “ Guanyl-nucleinsaure.” As early as January, 1919, I isolated and described a “Guanylnucleinsaure” (Feulgen). In January of the same year the results were presented in a manuscript to the authorities entrusted with the appointment of a chemist at the Caroline Institute. I did not wish to publish my results, because of the incompleteness of the investigation at the time. My results are essentially in accord with those of Feulgen, and the confirmation seems to be of sufficient value to justify publication. Following is a summary of the most important of my results, up to January, 1919. The method of preparing the nucleic acid had been worked out in the form described below.
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تاریخ انتشار 2003